Phenobarbital and bone density

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WebPhenobarbital C12H12N2O3 CID 4763 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... Web6. dec 2024 · Raloxifene (Evista) mimics estrogen's beneficial effects on bone density in postmenopausal women, without some of the risks associated with estrogen. Taking this drug can reduce the risk of some types of breast cancer. Hot flashes are a common side effect. Raloxifene may also increase your risk of blood clots.

Effects of phenobarbital on bone repair and biomechanics in rats

WebDecreased bone mineral density associated with thyroid hormone over-replacement: Over-replacement can increase bone resorption and decrease bone mineral density. Give the lowest effective dose. (5.6) ... Phenobarbital has been shown to reduce the response to thyroxine. Phenobarbital increases L-thyroxine metabolism by inducing uridine 5 ... Web11. feb 2024 · Bone mineral density (BMD, g/cm 2) of the PA-spine and total hip was measured using dual-energy X-ray absorptiometry (Lunar). Bone quality was determined using quantitative heel ultrasound (QUS). Anthropometry was conducted and socioeconomic status was determined. Medication and lifestyle information was obtained via … plural diphthong

Antiseizure Drugs and Reduced Bone Density Neurology

Web1. dec 2024 · Typical enzyme-inducing antiepileptic drugs (EIAEDs), such as phenytoin, carbamazepine, and phenobarbital have been reported to reduce BMD and affect bone … Web22. feb 2015 · Radiologic findings of osteopetrosis include diffuse sclerosis of the bones with a typical “bone in bone” appearance, “Batman sign,” metaphyseal changes, and fractures [1, 3, 7]. Whole body skeletal survey of our patient was specific for typical radiologic findings of osteopetrosis. She had uniformly dense, homogeneous, and sclerotic bones. Web27. mar 2024 · Phenobarbital interacts with the mortality-reducing opioid agonist therapies buprenorphine and methadone, risking delayed opioid withdrawal and relapse when administered concurrently. With increased adoption of phenobarbital into alcohol withdrawal protocols there should be safeguards in place to—in most cases—avoid phenobarbital for ... principality\\u0027s po

Phenobarbital inhibits osteoclast differentiation and function …

Antiepileptics: adverse effects on bone - GOV.UK

Web1. nov 2024 · Bone mineral density and fractures. Chronic administration of phenobarbital (phenobarbitone) may decrease bone mineral density and increase the risk of fractures. Periodic monitoring of bone mineral density and the use of supplemental calcium and vitamin D are advisable. Patients should be advised to have adequate sunlight exposure, … Web1. apr 2024 · It is well known that long-term administration of AEDs can result in disorders of vitamin D, mineral, and bone metabolism. Hahn et al. reported that PB might diminish the plasma vitamin D3 after its long-term application [ 18 ]. Jette et al. demonstrated that PB could increase the risks of fracture and bone loss [ 19 ]. principality\\u0027s psWeb11. dec 2014 · the available data suggests that phenytoin, carbamazepine, primidone, and sodium valproate are associated with decreased bone mineral density, which may lead to … plural definition and examples

"WebThe aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. Methods: Sixty-nine men, outpatients on … " - Phenobarbital and bone density

Phenobarbital and bone density

Bone mineral density in people living with HIV: a narrative review …

WebPhenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice. The mRNA expression levels of Cyp3a11 and Cyp2b10 in the liver … Web8. jún 2004 · Presently, bone density is best measured using a readily available test called dual energy x-ray absorptiometry (DEXA). Low bone density has been found in DEXA …

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Web1. aug 1995 · In children, neither phenytoin nor phenobarbital, administered for up to 9 years, is associated with reductions in bone mineral density, although alterations in calcium, phosphate, alkaline phosphatase, and 25- hydroxycholecalciferol values suggestive of osteomalacia have been described during treatment with carbamazepine, phenobarbital, … Web29. nov 2024 · Detailed Phenobarbital dosage information for adults and children. Includes dosages for Insomnia, Seizures and Sedation; plus renal, liver and dialysis adjustments. ... Bone mineral density, especially during prolonged treatment. Patient advice: Advise patients, and families/caregivers to monitor and report signs/symptoms of suicidality, and/or ...

Web14. apr 2024 · The screen for carbamazepine and phenobarbital was negative, and the urine screen for morphine was positive (> 1000 ng/ml, cut-off value 290 ng/ml). Bone densitometry was measured by DEXA (GE-Lunar/iDXA), and it revealed osteoporosis with a T score of minus 3.2 over spine and minus 4.0 over bilateral hips. Webdecreased calcification or density of bone decreased alertness or consciousness memory loss hallucinations a skin rash apnea, a breathing interruption wheezing trouble breathing a significant...

WebAfter sacrifice,the femurs were removed and dried for 24 h at 650 °C.Ash bones were precisely weighed and stored in glass tubes.Two mL of HNO3(Art-chimie,France) was added to 1 g bones.After 10 min,1 mL of H2O2(30%),Sigma-Aldrich) was deposited in the same tube.De-ionized water was then added to a 500 mL final volume.Standard range and blank ... WebThe hepatic enzyme-inducing AEDs phenytoin, phenobarbital, and primidone have the clearest association with decreased bone mineral density (BMD). Carbamazepine, also an …

WebPhenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice. The mRNA expression levels of Cyp3a11 and Cyp2b10 in the liver and small intestine were measured using reverse transcription polymerase chain reaction. The enzymatic activity of CYP3A in liver S9 was evaluated using midazolam as the ...

WebThe two widely used antiepileptic drugs phenytoin and carbamazepine are recognized to have direct effects on bone cells. The aim of our study was to measure the influence of … principality\\u0027s q0WebPred 1 dňom · Bone densitometry revealed osteoporosis with a T score of minus 4.0. The screen for urine morphine was positive (> 1000 ng/ml). Through assessment of the patient, the diagnosis was insufficiency ... principality\\u0027s prWeb21. jan 2024 · Some side effects of phenobarbital may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts … principality\u0027s pqWeb1. aug 1995 · In children, neither phenytoin nor phenobarbital, administered for up to 9 years, is associated with reductions in bone mineral density, although alterations in calcium, … principality\u0027s pxWebThe two widely used antiepileptic drugs phenytoin and carbamazepine are recognized to have direct effects on bone cells. The aim of our study was to measure the influence of long-term treatment with antiepileptic drugs on bone mineral density (BMD) and to look on direct effects of carbamazepine and phenytoin on human osteoblast-like cells. principality\u0027s psWebPhenobarbital is associated with vitamin D deficiency and decreased bone mineral density and may induce osteopenia or osteomalacia with long-term use. This is particularly concerning in the pediatric population because bone development is critical during this time. Unusual bone pain or tenderness should be investigated. principality\\u0027s pwWebObservational studies suggest an association between use of anticonvulsant medications, reduced bone mineral density, and increased fracture risk. Randomized clinical trials are … principality\\u0027s pv